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Other similar models in chickens [89] and rabbits [90] encoun-tered the same problem, describing narrow safety margins in inoculum dose when admin-istered systemically.

In Goodpasture syndrome, IgGs bind to the NC1 domain of type IV collagen (a3 chain) found in the GBM. The lipid isthen discharged into the intercellular space

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Ferrous iron-mediated cleavage ofthe bridge releases a highly reactive free radicalspecies that binds to membrane proteins, causeslipid peroxidation, damages endoplasmicreticulum, and ultimately results in lysis of theparasite.

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